X linked recessive disease which causes defective G6PD enzyme.
It it reduces or eliminates hemoglobin synthesis. The spleen destroys red blood cells which creates severe anaemia.
Fatigue. Weak bones. Heart disease.
High frequency in Mediterranean about 80% and African descent. Kurdish Jews.
But it provides resistance to malaria which creates selective advantage in heterozygous people
Almost exclusive in males because x-linked disease.
400 million people suffer.
Usually they may no show any symptoms but after eating fava beans for or sulphur based antibiotics or Blood transfusion. They will face nausea heavy breathing dark urine anaemia and even death.
Sara identifies origin to 10,000 years ago.
Archeologists in China have discovered two engraved bones with ochre incisions in a layer dating back between 105,000 and 125,000 years ago, which they say is the earliest evidence of human populations using ochre — an earthy pigment — for symbolic purposes. Hunan province. 2019 Indian Express.
PNAS now says that modern humans interbred with two other extinct early human species. Joao Teixeira of the University of Adelaide, Australia, and the lead author of the PNAS paper, said, “Each of us carry within ourselves the genetic traces of these past mixing events. These archaic groups were widespread and genetically diverse, and they survive in each of us. Their story is an integral part of how we came to be.” PNAS 2019.